Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.45 |
| ▸ | CDK4 | P11802 | 5/20 | 0.45 |
| ▸ | IKBKB | O14920 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606156 | 0.84 | CDK2 (0.52) | CDK2CDK4IKBKBCDK1CCNT1 | |
| SCHEMBL5098684 | 0.78 | CDK2 (0.59) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL6603829 | 0.77 | CDK2 (0.48) | CDK2CDK4IKBKBCDK1CCNT1 | |
| SCHEMBL6621757 | 0.76 | CDK2 (0.51) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL5915726 | 0.74 | CDK2 (0.66) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL6384379 | 0.74 | CDK2 (0.56) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL6382091 | 0.73 | CDK2 (0.48) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL6821901 | 0.72 | CDK2 (0.62) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL6606019 | 0.72 | CDK2 (0.64) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL5098655 | 0.72 | CDK2 (0.59) | CDK2CDK4IKBKBCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |