Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.50 |
| ▸ | CDK4 | P11802 | 7/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | PLK1 | P53350 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606511 | 0.86 | CDK2 (0.47) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL6606903 | 0.82 | CDK2 (0.52) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL6604144 | 0.75 | CDK2 (0.55) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL5095453 | 0.71 | KDR (0.48) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL6621511 | 0.71 | CDK2 (0.52) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL6634930 | 0.67 | CDK2 (0.46) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL6606433 | 0.67 | CDK2 (0.46) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL2284091 | 0.67 | CDK2 (1.00) | CDK2CDK4CCNE1PLK1CDK1 | |
| SCHEMBL1415012 | 0.67 | CDK2 (0.67) | CDK2CDK4CCNE1PLK1JAK2 | |
| SCHEMBL6106023 | 0.67 | CDK2 (0.56) | CDK2CDK4CCNE1PLK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |