Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 3/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
| ▸ | TACR3 | P29371 | 3/20 | 0.39 |
| ▸ | PTGFR | P43088 | 17/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14485492 | 0.92 | TACR2 (0.36) | TACR2TACR1TACR3PTGFR | |
| SCHEMBL4025552 | 0.91 | TACR2 (0.45) | TACR2TACR1TACR3PTGFR | |
| SCHEMBL4025558 | 0.91 | TACR2 (0.45) | TACR2TACR1TACR3PTGFR | |
| SCHEMBL14484775 | 0.91 | TACR2 (0.36) | TACR2TACR1TACR3PTGFR | |
| SCHEMBL14484958 | 0.90 | TACR2 (0.36) | TACR2TACR1TACR3 | |
| SCHEMBL14484758 | 0.89 | TACR2 (0.39) | TACR2TACR1TACR3PTGFR | |
| SCHEMBL14485288 | 0.89 | TACR2 (0.38) | TACR2TACR1TACR3PTGFR | |
| SCHEMBL6605525 | 0.88 | TACR2 (0.37) | TACR2TACR1TACR3PTGFRTBXA2R | |
| SCHEMBL14144503 | 0.88 | TACR2 (0.41) | TACR2TACR1TACR3PTGFRTBXA2R | |
| SCHEMBL6609096 | 0.87 | TACR2 (0.42) | TACR2TACR1TACR3PTGFRADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1119551-B1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1433783-A2 | Naphthalenecarboxamides as tachykinin receptor antagonists | AstraZeneca AB (SE) | 2004-06-30 | — | — | EP | disclosed |
| EP-1119551-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000020389-A1 | NAPHTHALENECARBOXAMIDES AS TACHYKININ RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-04-13 | — | — | WO | disclosed |