Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.47 |
| ▸ | PPARA | Q07869 | 11/20 | 0.47 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603331 | 0.91 | PPARA (0.47) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL6607542 | 0.86 | PPARG (0.46) | PPARGPPARAPPARDNPC1RAB9A | |
| SCHEMBL26062737 | 0.84 | PPARG (0.47) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL6606425 | 0.84 | KDM4E (0.49) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL13960245 | 0.82 | KDM4E (0.49) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL5022312 | 0.82 | KDM4E (0.61) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL6607539 | 0.81 | MEN1 (0.42) | KDM4ENPC1RAB9AHPGDALDH1A1 | |
| SCHEMBL5111146 | 0.81 | PPARA (0.48) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL13341901 | 0.78 | KDM4E (0.45) | PPARGPPARAPPARDKDM4ENPC1 | |
| SCHEMBL5858351 | 0.78 | PPARG (0.60) | PPARGPPARAPPARDKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102757-B1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6498174-B1 | AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| EP-1102757-A1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008002-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |