Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.46 |
| ▸ | CDK4 | P11802 | 7/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608947 | 0.91 | CDK2 (0.43) | CDK2CDK4IKBKBCDK1KCNH2 | |
| SCHEMBL6608941 | 0.86 | CDK2 (0.44) | CDK2CDK4IKBKBCDK1SYK | |
| SCHEMBL6606819 | 0.85 | CDK2 (0.41) | CDK2CDK4IKBKBCDK1KCNH2 | |
| SCHEMBL6608943 | 0.83 | CDK2 (0.42) | CDK2CDK4IKBKBCDK1KCNH2 | |
| SCHEMBL5095462 | 0.83 | CDK2 (0.51) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL5101838 | 0.79 | CDK2 (0.53) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL6606812 | 0.75 | CDK2 (0.40) | CDK2CDK4IKBKBCDK1SYK | |
| SCHEMBL5108289 | 0.73 | CDK2 (0.49) | CDK2CDK4CDK1 | |
| SCHEMBL5783474 | 0.70 | CDK2 (0.59) | CDK2CDK4IKBKBCDK1SYK | |
| SCHEMBL5781715 | 0.69 | PRKCD (0.51) | CDK2CDK4IKBKBCDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490354-A1 | 4-IMIDAZOLYL SUBSTITUTED PYRIMIDINE DERIVATIVES WITH CDK INHIBITORY ACTIVITY | Astrazeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003076434-A1 | 4- IMIDAZOLYL SUBSTUITED PYRIMIDINE DERIVATIVES WITH CDK INHIBITIORY ACTIVITY | ASTRAZENECA AB (SE) | 2003-09-18 | — | — | WO | disclosed |