Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 7/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 7/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 7/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.33 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6376380 | 0.88 | HSD17B10 (0.34) | GRIA1GRIA2GRIA3GRIA4TP53 | |
| SCHEMBL6375989 | 0.88 | MAPT (0.38) | GRIA1GRIA2GRIA3GRIA4TP53 | |
| Hydrochloric Acid SCHEMBL6603295 | 0.85 | GRIA1 (0.48) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6602707 | 0.77 | GRIA1 (0.69) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| Hydrochloric Acid SCHEMBL6606845 | 0.77 | GRIA1 (0.34) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6603338 | 0.75 | KDM4E (0.36) | TP53POLBMAPTKDM4EMEN1 | |
| SCHEMBL6605459 | 0.75 | GRIA1 (0.56) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6602507 | 0.72 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL9704892 | 0.71 | MAPT (0.46) | TP53POLBMAPTKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL6378430 | 0.71 | TP53 (0.34) | GRIA1GRIA2GRIA3GRIA4GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020453-B1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERIVATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN SEIYAKU KK (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6348461-B1 | CENTRAL NERVOUS SYSTEM ANTAGONIST WITH HETEROCYCLIC SUBSTITUENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| EP-1020453-A1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |