SCHEMBL6605534

SCHEMBL6605534

Cc1nnc(-c2ccc(C)c(-c3ccc(C(=O)NCc4cccc(Cl)c4)cc3)c2)o1.Cc1nnc(-c2ccc(C)c(-c3ccc(C(=O)NCc4cccc(Cl)c4)cc3)c2)o1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 19/20 0.80
MAPK11 Q15759 2/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4859805 1.00 MAPK14 (0.80) MAPK14MAPK11
SCHEMBL4862300 0.90 MAPK14 (0.83) MAPK14MAPK11
Gw708893X SCHEMBL4856407 0.89 MAPK14 (1.00) MAPK14MAPK11
SCHEMBL4863522 0.89 MAPK14 (1.00) MAPK14MAPK11
SCHEMBL4862324 0.88 MAPK14 (0.79) MAPK14MAPK11
SCHEMBL4862298 0.87 MAPK14 (0.77) MAPK14MAPK11
SCHEMBL4854275 0.87 MAPK14 (1.00) MAPK14MAPK11
SCHEMBL4858185 0.86 MAPK14 (0.76) MAPK14MAPK11
SCHEMBL4864471 0.86 MAPK14 (0.76) MAPK14MAPK11
SCHEMBL4855124 0.85 MAPK14 (0.85) MAPK14MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1435949-A1 2' -METHYL-5-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS GLAXO GROUP LIMITED (GB) 2004-07-14 EP disclosed
WO-2003032986-A1 2' -METHYL-5-(1,3,4-OXADIAZOL-2-YL)-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS GLAXO GROUP LIMITED (GB) 2003-04-24 WO disclosed