Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 5/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11010422 | 0.85 | KDM4E (0.49) | KDM4EPPARGPPARAPPARDLMNA | |
| SCHEMBL4030027 | 0.83 | KDM4E (0.76) | KDM4EPPARGPPARAPPARDRAB9A | |
| SCHEMBL13115729 | 0.82 | KDM4E (0.54) | KDM4EPPARGPPARAPPARDRAB9A | |
| SCHEMBL6604396 | 0.82 | MEN1 (0.43) | KDM4EPPARGPPARAPPARDRAB9A | |
| SCHEMBL6608776 | 0.80 | PPARG (0.42) | PPARGPPARAPPARDRAB9AMEN1 | |
| SCHEMBL6602803 | 0.80 | TARBP2 (0.52) | PPARGPPARAPPARDMEN1KMT2A | |
| SCHEMBL11008810 | 0.80 | KDM4E (0.51) | KDM4EPPARGPPARAPPARDLMNA | |
| SCHEMBL13115484 | 0.79 | KDM4E (0.61) | KDM4EPPARGPPARAKMT2ALMNA | |
| SCHEMBL6607542 | 0.78 | PPARG (0.46) | PPARGPPARAPPARDRAB9AMEN1 | |
| SCHEMBL2818553 | 0.77 | TP53 (0.49) | KDM4ERAB9ALMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102757-B1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6498174-B1 | AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |