Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.51 |
| ▸ | KIF20A | O95235 | 4/20 | 0.51 |
| ▸ | CLK1 | P49759 | 4/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605953 | 1.00 | KDM4E (0.53) | KDM4ENPC1POLBRAB9ADYRK1A | |
| SCHEMBL6606109 | 0.90 | MAPT (0.47) | KDM4ENPC1POLBRAB9APDE4D | |
| SCHEMBL6606116 | 0.90 | MAPT (0.47) | KDM4ENPC1POLBRAB9APDE4D | |
| SCHEMBL6609041 | 0.89 | PDE4D (0.45) | PDE4DEGFRSMN1; SMN2RECQLHIF1A | |
| SCHEMBL6609046 | 0.89 | PDE4D (0.45) | PDE4DEGFRSMN1; SMN2RECQLHIF1A | |
| SCHEMBL6609611 | 0.84 | PDE4B (0.43) | NPC1POLBRAB9APDE4DEGFR | |
| SCHEMBL6609617 | 0.84 | PDE4B (0.43) | NPC1POLBRAB9APDE4DEGFR | |
| SCHEMBL6607722 | 0.83 | PDE4B (0.44) | PDE4DEGFRMAPTPDE4AKMT2A | |
| SCHEMBL6607729 | 0.83 | PDE4B (0.44) | PDE4DEGFRMAPTPDE4AKMT2A | |
| SCHEMBL6609810 | 0.83 | KDM4E (0.52) | KDM4ENPC1POLBRAB9ADYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |