Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | SCD | O00767 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL773697 | 0.88 | LCK (0.63) | LCKLMNAGAASCDMEN1 | |
| SCHEMBL14568890 | 0.88 | LCK (0.74) | LCKLMNAGAASCDALDH1A1 | |
| SCHEMBL773925 | 0.87 | LCK (0.74) | LCKGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL774286 | 0.87 | LCK (0.67) | LCKLMNAGAASCDMEN1 | |
| SCHEMBL774411 | 0.87 | LCK (0.60) | LCKLMNAGAASCDMEN1 | |
| SCHEMBL774155 | 0.85 | LCK (0.58) | LCKLMNAGAASCDMEN1 | |
| SCHEMBL774405 | 0.84 | LCK (0.64) | LCKLMNAGAASCDMEN1 | |
| SCHEMBL774504 | 0.83 | LCK (0.71) | LCKLMNAGAASCDMEN1 | |
| SCHEMBL1541493 | 0.83 | LCK (0.71) | LCKMEN1KMT2AALDH1A1POLB | |
| SCHEMBL1540156 | 0.83 | LCK (0.74) | LCKMEN1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169038-A4 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2004-10-13 | — | — | EP | claimed |
| EP-1169038-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-01-09 | — | — | EP | claimed |
| WO-2000062778-A1 | CYCLIC PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB CO. (US) | 2000-10-26 | — | — | WO | claimed |