Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 16/20 | 0.67 |
| ▸ | HTR1D | P28221 | 14/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | GHSR | Q92847 | 3/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606338 | 1.00 | HTR1B (0.67) | HTR1BHTR1DHTR1AGHSRP2RX7 | |
| SCHEMBL6606597 | 0.90 | HTR1D (0.55) | HTR1BHTR1DP2RX7 | |
| SCHEMBL6606601 | 0.90 | HTR1D (0.55) | HTR1BHTR1DP2RX7 | |
| SCHEMBL6604237 | 0.80 | HTR1B (1.00) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6604234 | 0.80 | HTR1B (1.00) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6604349 | 0.79 | HTR1D (0.54) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6604346 | 0.79 | HTR1D (0.54) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6603928 | 0.76 | HTR1B (0.57) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6603932 | 0.76 | HTR1B (0.57) | HTR1BHTR1DHTR1AGHSR | |
| SCHEMBL6605206 | 0.75 | HTR1D (0.42) | HTR1BHTR1DP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | claimed |
| EP-1487806-A1 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | Astrazeneca AB (SE) | 2004-12-22 | — | — | EP | disclosed |
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | disclosed |
| WO-2003082831-A1 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |