Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | EIF4EBP1 | Q13541 | 14/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602054 | 0.94 | PTPN11 (0.40) | PTPN11EIF4EBP1TP53MDM2KMT2A | |
| SCHEMBL6602497 | 0.92 | PLAU (0.40) | KMT2ARXFP1 | |
| SCHEMBL6803634 | 0.92 | TP53 (0.39) | PTPN11TP53MDM2KMT2ARXFP1 | |
| SCHEMBL6607900 | 0.90 | RXFP1 (0.38) | KMT2ARXFP1 | |
| SCHEMBL6603696 | 0.86 | PTPN11 (0.41) | PTPN11EIF4EBP1KMT2ARXFP1 | |
| SCHEMBL6607170 | 0.86 | PLAU (0.40) | KMT2ARXFP1 | |
| SCHEMBL6613466 | 0.85 | TP53 (0.43) | PTPN11TP53MDM2KMT2ARXFP1 | |
| SCHEMBL6803979 | 0.85 | MAPT (0.37) | KMT2ARXFP1 | |
| SCHEMBL6605028 | 0.84 | PTPN11 (0.39) | PTPN11EIF4EBP1KMT2ARXFP1 | |
| SCHEMBL6602524 | 0.83 | ADORA1 (0.40) | TP53MDM2KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-1432689-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | Bayer Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027074-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | MKI67, CDK4, FLT4 | PTPN11 3094/4885EIF4EBP1 2524/4885TP53 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.