Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.49 |
| ▸ | PDE4A | P27815 | 12/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.49 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606630 | 1.00 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CTRPC6 | |
| SCHEMBL6609414 | 0.81 | PDE4B (0.45) | PDE4DPDE4APDE4BPDE4CTRPC6 | |
| SCHEMBL6609416 | 0.81 | PDE4B (0.45) | PDE4DPDE4APDE4BPDE4CTRPC6 | |
| SCHEMBL72555 | 0.78 | PDE4D (0.73) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL71286 | 0.78 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL72957 | 0.77 | PDE4A (0.58) | PDE4DPDE4APDE4BPDE4CTRPC6 | |
| SCHEMBL70981 | 0.74 | PDE4B (0.64) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL70423 | 0.73 | PDE4A (0.57) | PDE4DPDE4APDE4BPDE4CTRPC6 | |
| SCHEMBL71422 | 0.73 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4CKMT2A | |
| SCHEMBL6610551 | 0.72 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |