Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.50 |
| ▸ | PDE4A | P27815 | 10/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609594 | 0.85 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL6611448 | 0.84 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7362274 | 0.79 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL6605575 | 0.78 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL6612105 | 0.77 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL9182582 | 0.73 | KMT2A (0.42) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL6609750 | 0.73 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6606602 | 0.71 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7270534 | 0.71 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDGFRB | |
| SCHEMBL7289526 | 0.71 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |