SCHEMBL6607677

SCHEMBL6607677

Cc1ccc(-c2cc(N)c(C(N)=O)s2)s1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC7 O00311 1/20 0.58
DBF4 Q9UBU7 1/20 0.58
IKBKB O14920 8/20 0.57
CYP1A2 P05177 3/20 0.57
CYP2C9 P11712 3/20 0.57
CYP3A4 P08684 2/20 0.57
BTK Q06187 1/20 0.57
CYP2C19 P33261 2/20 0.54
CHUK O15111 1/20 0.54
MAPT P10636 11/20 0.53
ALDH1A1 P00352 6/20 0.53
HDAC6 Q9UBN7 1/20 0.53
KDM4E B2RXH2 8/20 0.44
LMNA P02545 1/20 0.44
PKM P14618 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
NPC1 O15118 7/20 0.42
LIMK1 P53667 1/20 0.42
POLB P06746 1/20 0.42
RAB9A P51151 5/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6609347 0.81 IKBKB (0.64) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL6611685 0.77 IKBKB (0.72) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL15943484 0.76 IKBKB (0.50) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL6610791 0.75 IKBKB (0.51) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL4087590 0.73 MAPT (0.68) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL612267 0.73 CDC7 (1.00) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL6607937 0.73 IKBKB (0.74) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL6610388 0.73 IKBKB (0.53) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL6612593 0.72 IKBKB (0.76) CDC7DBF4IKBKBCYP1A2CYP2C9
SCHEMBL1847243 0.72 IKBKB (1.00) CDC7DBF4IKBKBCYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1444010-A2 HETEROAROMATIC CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION Pharmacia Corporation (US) 2004-08-11 EP claimed
WO-2003037886-A2 HETEROAROMATIC CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION PHARMACIA CORPORATION (US) 2003-05-08 WO claimed
EP-1444010-A2 HETEROAROMATIC CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION Pharmacia Corporation (US) 2004-08-11 EP disclosed
WO-2003037886-A2 HETEROAROMATIC CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION PHARMACIA CORPORATION (US) 2003-05-08 WO disclosed