Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE1A | P54750 | 1/20 | 0.38 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | IGF2R | P11717 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607991 | 1.00 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6607729 | 0.87 | PDE4B (0.44) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6607722 | 0.87 | PDE4B (0.44) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6606109 | 0.83 | MAPT (0.47) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6606116 | 0.83 | MAPT (0.47) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6610551 | 0.82 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6610555 | 0.82 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6606614 | 0.82 | PDE4B (0.43) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6606617 | 0.82 | PDE4B (0.43) | PDE4DPDE4APDE4BPDE4CMEN1 | |
| SCHEMBL6611535 | 0.80 | PDE4D (0.39) | PDE4DPDE4APDE4BPDE4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |