Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL660812 | 1.00 | MDM2 (0.90) | MDM2TP53 | |
| SCHEMBL659850 | 0.95 | MDM2 (0.91) | MDM2TP53 | |
| SCHEMBL659851 | 0.95 | MDM2 (0.91) | MDM2TP53 | |
| SCHEMBL658271 | 0.95 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL658927 | 0.95 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL658272 | 0.95 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL29434936 | 0.95 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL30101657 | 0.95 | MDM2 (1.00) | MDM2TP53 | |
| SCHEMBL660238 | 0.94 | MDM2 (0.90) | MDM2TP53 | |
| SCHEMBL660081 | 0.94 | MDM2 (0.81) | MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046306-A1 | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists | BARTKOVITZ DAVID JOSEPH (US) | 2012-02-23 | — | — | US | claimed |
| US-20120046306-A1 | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists | BARTKOVITZ DAVID JOSEPH (US) | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046306-A1 | Substituted Heteroaryl Spiropyrrolidine MDM2 Antagonists | MDM2, TP53, RB1 | MDM2 1/4885TP53 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.