Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 20/20 | 0.65 |
| ▸ | TAB1 | Q15750 | 20/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10218683 | 0.94 | MAP3K7 (0.73) | MAP3K7TAB1KDRAURKB | |
| Trifluoroacetic Acid SCHEMBL660296 | 0.93 | MAP3K7 (0.64) | MAP3K7TAB1KDRAURKB | |
| Trifluoroacetic Acid SCHEMBL661445 | 0.92 | MAP3K7 (0.71) | MAP3K7TAB1 | |
| Trifluoroacetic Acid SCHEMBL659799 | 0.90 | MAP3K7 (0.64) | MAP3K7TAB1KDRAURKB | |
| Trifluoroacetic Acid SCHEMBL662033 | 0.90 | MAP3K7 (0.64) | MAP3K7TAB1KDRAURKB | |
| SCHEMBL660850 | 0.90 | MAP3K7 (0.56) | MAP3K7TAB1KDRAURKB | |
| SCHEMBL660851 | 0.90 | MAP3K7 (0.56) | MAP3K7TAB1KDRAURKB | |
| Trifluoroacetic Acid SCHEMBL657743 | 0.88 | MAP3K7 (0.62) | MAP3K7TAB1KDRAURKB | |
| SCHEMBL10218719 | 0.87 | MAP3K7 (0.71) | MAP3K7TAB1KDRAURKB | |
| SCHEMBL10218673 | 0.86 | MAP3K7 (0.77) | MAP3K7TAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378104-B2 | 7-aminofuropyridine derivatives | OSI Pharmaceuticals, LLC (US) | 2013-02-19 | — | — | US | disclosed |
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2012-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046267-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | MAP3K5, STK17A, MAPKAPK5 | MAP3K7 5/4885TAB1 4/4885KDR 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.