Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 8/20 | 0.65 |
| ▸ | EGFR | P00533 | 14/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | LYN | P07948 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.58 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.58 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.58 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.58 |
| ▸ | EPHA5 | P54756 | 1/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.58 |
| ▸ | EPHA4 | P54764 | 1/20 | 0.58 |
| ▸ | ADK | P55263 | 1/20 | 0.58 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.58 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134522 | 1.00 | ERBB2 (0.65) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3129383 | 0.93 | EGFR (0.64) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL6605775 | 0.93 | EGFR (0.64) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL6609954 | 0.93 | EGFR (0.64) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3121097 | 0.93 | EGFR (0.64) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3121680 | 0.88 | EGFR (0.66) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL6608889 | 0.88 | EGFR (0.66) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3132214 | 0.88 | ERBB2 (0.71) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL4922965 | 0.88 | ERBB2 (0.71) | ERBB2EGFRGAKRIPK2LYN | |
| SCHEMBL3127206 | 0.88 | ERBB2 (0.71) | ERBB2EGFRGAKRIPK2LYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487806-A1 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | Astrazeneca AB (SE) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082831-A1 | 4-ANILINO QUINAZOLINE DERIVATIVES AS ANTIPROLIFERATIVE AGENTS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |