Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 20/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.64 |
| ▸ | CDK9 | P50750 | 1/20 | 0.64 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.61 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 10/20 | 0.56 |
| ▸ | GSK3B | P49841 | 7/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6624523 | 0.97 | CDK2 (0.67) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL6609042 | 0.97 | CDK2 (0.70) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL6607499 | 0.84 | CDK2 (0.63) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL5867851 | 0.84 | CDK2 (0.86) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL6624125 | 0.84 | CDK2 (0.56) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL6625115 | 0.83 | CDK2 (0.57) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL5495592 | 0.83 | CDK2 (0.63) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL6617840 | 0.83 | CDK2 (0.63) | CDK2CDK5CDK9CCNA2CCNA1 | |
| SCHEMBL6610610 | 0.83 | CCNA2 (0.53) | CDK2CCNA2CCNA1 | |
| SCHEMBL6605544 | 0.82 | CDK2 (0.60) | CDK2CDK5CDK9CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040116497-A1 | Chromane derivatives, process for their preparation and their use as antitumor agents | PHARMACIA ITALIA SPA (IT) | 2004-06-17 | — | — | US | claimed |
| EP-1379524-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2004-01-14 | — | — | EP | claimed |
| WO-2002070515-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2002-09-12 | — | — | WO | claimed |
| US-20040116497-A1 | Chromane derivatives, process for their preparation and their use as antitumor agents | PHARMACIA ITALIA SPA (IT) | 2004-06-17 | — | — | US | disclosed |
| EP-1379524-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002070515-A2 | CHROMANE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2002-09-12 | — | — | WO | disclosed |