Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.67 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10024195 | 0.95 | HDAC1 (0.64) | HDAC1HDAC8HAO1GSK3BHDAC3 | |
| SCHEMBL5663139 | 0.95 | HDAC1 (0.64) | HDAC1HDAC8GSK3BHDAC3HDAC4 | |
| SCHEMBL8674579 | 0.93 | HDAC8 (0.67) | HDAC1HDAC8GSK3BHDAC3HDAC4 | |
| SCHEMBL1502426 | 0.89 | HDAC1 (0.61) | HDAC1HDAC8GSK3BHDAC3HDAC4 | |
| SCHEMBL6613324 | 0.85 | HDAC1 (0.54) | HDAC1HDAC8GSK3BHDAC3HDAC4 | |
| SCHEMBL133319 | 0.85 | HDAC1 (0.75) | HDAC1HDAC8GSK3BHDAC3HDAC4 | |
| SCHEMBL13670556 | 0.84 | HDAC1 (0.69) | HDAC1HDAC8HAO1GSK3BHDAC3 | |
| SCHEMBL6610437 | 0.84 | HDAC1 (0.64) | HDAC1HDAC8HAO1GSK3BHDAC3 | |
| SCHEMBL4453540 | 0.83 | HDAC1 (0.71) | HDAC1HDAC8HAO1GSK3BHDAC3 | |
| SCHEMBL3380464 | 0.83 | HDAC8 (0.71) | HDAC1HDAC8HAO1GSK3BHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | disclosed |