Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HMOX1 | P09601 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9552832 | 0.98 | TAAR1 (0.45) | MAPK1NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL28594032 | 0.94 | TAAR1 (0.48) | MAPK1NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL9552525 | 0.87 | HRH3 (0.43) | RAB9ASMN1; SMN2HDAC2HDAC1TSHR | |
| SCHEMBL9553269 | 0.87 | HRH3 (0.43) | RAB9ASMN1; SMN2HDAC2HDAC1TSHR | |
| SCHEMBL7961204 | 0.85 | TAAR1 (0.52) | MAPK1NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL9553087 | 0.83 | TAAR1 (0.50) | MAPK1NPC1NFKB1RAB9ANFKB2 | |
| SCHEMBL23837667 | 0.82 | ESR1 (0.44) | HTR2AHSD17B10ALDH1A1SIGMAR1 | |
| SCHEMBL18440450 | 0.82 | ESR1 (0.44) | HTR2AHSD17B10ALDH1A1SIGMAR1 | |
| SCHEMBL15583726 | 0.82 | TAAR1 (0.59) | TAAR1HTR2AHMOX1HSD17B10ALDH1A1 | |
| SCHEMBL134452 | 0.82 | TAAR1 (0.59) | TAAR1HTR2AHMOX1HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | disclosed |