Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.40 |
| ▸ | PDE4A | P27815 | 12/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609229 | 1.00 | POLB (0.40) | POLBPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6609416 | 0.90 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4CCHEK1 | |
| SCHEMBL6609414 | 0.90 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4CCHEK1 | |
| SCHEMBL6610689 | 0.81 | CHEK1 (0.36) | PDE4BPDE4DPDE4APDE4CCHEK1 | |
| SCHEMBL6610555 | 0.81 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL6610551 | 0.81 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL6606617 | 0.80 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL6606614 | 0.80 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CMEN1 | |
| SCHEMBL6609466 | 0.78 | PDE4D (0.41) | PDE4BPDE4DPDE4APDE4CCHEK1 | |
| SCHEMBL6609471 | 0.78 | PDE4D (0.41) | PDE4BPDE4DPDE4APDE4CCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |