Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.74 |
| ▸ | PPARA | Q07869 | 3/20 | 0.74 |
| ▸ | PPARD | Q03181 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6610462 | 0.92 | PPARG (0.71) | PPARGPPARAPPARD | |
| SCHEMBL6611072 | 0.87 | PPARG (0.77) | PPARGPPARAPPARD | |
| SCHEMBL6612054 | 0.87 | PPARG (0.76) | PPARGPPARAPPARD | |
| SCHEMBL6608387 | 0.85 | PPARG (0.74) | PPARGPPARAPPARD | |
| SCHEMBL6608994 | 0.85 | PPARG (0.74) | PPARGPPARAPPARD | |
| Farglitazar SCHEMBL2208414 | 0.85 | PPARG (1.00) | PPARGPPARAPPARD | |
| Farglitazar SCHEMBL501024 | 0.85 | PPARG (1.00) | PPARGPPARAPPARD | |
| Farglitazar SCHEMBL14281408 | 0.85 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL6609331 | 0.85 | PPARG (0.73) | PPARGPPARAPPARD | |
| SCHEMBL5571080 | 0.85 | PPARG (0.73) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210345-B1 | OXAZOLE PPAR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2004-03-03 | — | — | EP | claimed |
| US-6506781-B1 | Prevent formation of a hydrogen bond between the agonist and tyrosine or histidine, or tryptophan involved in receptor activation; and/or b) displace the tyrosine or histidine, or tryptophan involved in receptor activation from its agonist | SMITHKLINE BEECHAM CORPORATION | 2003-01-14 | — | — | US | claimed |
| EP-1210345-A1 | OXAZOLE PPAR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2002-06-05 | — | — | EP | claimed |
| WO-2001017994-A1 | OXAZOLE PPAR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2001-03-15 | — | — | WO | claimed |
| EP-1210345-B1 | OXAZOLE PPAR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2004-03-03 | — | — | EP | disclosed |
| US-6506781-B1 | Prevent formation of a hydrogen bond between the agonist and tyrosine or histidine, or tryptophan involved in receptor activation; and/or b) displace the tyrosine or histidine, or tryptophan involved in receptor activation from its agonist | SMITHKLINE BEECHAM CORPORATION | 2003-01-14 | — | — | US | disclosed |
| EP-1210345-A1 | OXAZOLE PPAR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017994-A1 | OXAZOLE PPAR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2001-03-15 | — | — | WO | disclosed |