Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607118 | 0.85 | CYP17A1 (0.49) | PTPN1 | |
| SCHEMBL6606671 | 0.84 | SMN1; SMN2 (0.58) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL2092941 | 0.78 | SMN1; SMN2 (0.68) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL6642630 | 0.78 | TSHR (0.53) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL7251623 | 0.77 | SMN1; SMN2 (0.72) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL14556191 | 0.76 | MEN1 (0.56) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL9609808 | 0.75 | SMN1; SMN2 (0.82) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL6609313 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL282531 | 0.73 | SMN1; SMN2 (0.71) | SMN1; SMN2HPGDRAB9ANPC1MAPT | |
| SCHEMBL1415961 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2HPGDRAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423386-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-06-02 | — | — | EP | claimed |
| WO-2003022842-A1 | THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-20 | — | — | WO | claimed |