Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603893 | 0.91 | MCHR1 (0.61) | MEN1KMT2AMAPTMCHR1MET | |
| SCHEMBL7723576 | 0.90 | MAPT (0.53) | MEN1KMT2ACYP3A4CYP1A2CYP2C19 | |
| SCHEMBL6604936 | 0.85 | MEN1 (0.53) | MEN1KMT2AMAPTMCHR1MET | |
| SCHEMBL6602810 | 0.85 | MCHR1 (0.54) | MEN1KMT2AMAPTMCHR1MET | |
| SCHEMBL6604870 | 0.84 | MAPT (0.52) | MEN1KMT2ACYP3A4CYP1A2CYP2C19 | |
| SCHEMBL6603843 | 0.84 | NR1H4 (0.54) | MEN1KMT2AMAPTMCHR1 | |
| SCHEMBL6603526 | 0.82 | MAPT (0.44) | MEN1KMT2ACYP3A4CYP1A2CYP2C19 | |
| SCHEMBL6610208 | 0.81 | MCHR1 (0.63) | MAPTMCHR1ABL1BCRLMNA | |
| SCHEMBL6602555 | 0.80 | MAPT (0.52) | MEN1KMT2ACYP3A4CYP1A2CYP2C19 | |
| SCHEMBL6602805 | 0.80 | MCHR1 (0.62) | MEN1KMT2AMCHR1METEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |