Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.44 |
| ▸ | PDE4A | P27815 | 7/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609775 | 1.00 | PDE4B (0.44) | PDE4BPDE4DPDE4APDE4CCNR2 | |
| SCHEMBL8396444 | 0.85 | RECQL (0.36) | PDE4DRECQLSMN1; SMN2HIF1AEGFR | |
| SCHEMBL8396441 | 0.85 | RECQL (0.36) | PDE4DRECQLSMN1; SMN2HIF1AEGFR | |
| SCHEMBL6610767 | 0.85 | RECQL (0.36) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL6610774 | 0.85 | RECQL (0.36) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL6605361 | 0.84 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL6605364 | 0.84 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL6606241 | 0.84 | PDE4D (0.43) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL6610815 | 0.84 | SMN1; SMN2 (0.35) | PDE4BPDE4DPDE4APDE4CRECQL | |
| SCHEMBL6610811 | 0.84 | SMN1; SMN2 (0.35) | PDE4BPDE4DPDE4APDE4CRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0882714-B1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS PHARMACEUTICAL CO (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-5935977-A | PHOSPHODIESTERASE IV INHIBITORS, TUMOR NECROSIS FACTOR-ALPHA PRODUCTION INHIBITORS; TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES | SS PHARMACEUTICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0882714-A1 | SUBSTITUTED VINYLPYRIDINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SS Pharmaceutical Co., Ltd. (JP) | 1998-12-09 | — | — | EP | disclosed |