Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 6/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | KIT | P10721 | 5/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 8/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | TLK2 | Q86UE8 | 2/20 | 0.42 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.42 |
| ▸ | TLK1 | Q9UKI8 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | STK25 | O00506 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609953 | 1.00 | PDGFRB (0.48) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4998771 | 0.96 | PDGFRB (0.43) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4987712 | 0.96 | KDR (0.51) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4987717 | 0.96 | KDR (0.51) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4998774 | 0.96 | PDGFRB (0.43) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4995804 | 0.90 | FLT3 (0.43) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4995812 | 0.90 | FLT3 (0.43) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4994821 | 0.90 | FLT3 (0.50) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL4994823 | 0.90 | FLT3 (0.50) | PDGFRBKDRFGFR1KITFLT3 | |
| SCHEMBL6609271 | 0.90 | PDGFRB (0.53) | PDGFRBKDRFGFR1KITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |