Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridazine SCHEMBL16179268 | 0.94 | TSHR (0.42) | TSHRNAPRTTDP1 | |
| Pyrimidine SCHEMBL9310802 | 0.94 | TSHR (0.35) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL14833500 | 0.92 | TSHR (0.47) | TSHRNAPRTTDP1 | |
| Pyridazine SCHEMBL902443 | 0.90 | TSHR (0.47) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL27658382 | 0.88 | TSHR (0.50) | TSHRNAPRTTDP1 | |
| Pyridine SCHEMBL901848 | 0.84 | TSHR (0.60) | TSHRNAPRTTDP1 | |
| Pyridazine SCHEMBL4598491 | 0.84 | TSHR (0.50) | TSHRNAPRTTDP1 | |
| SCHEMBL5875298 | 0.83 | — | — | |
| Pyridazine SCHEMBL2491263 | 0.83 | TSHR (0.33) | TSHRNAPRTTDP1 | |
| Pyrazine SCHEMBL17100555 | 0.82 | TSHR (0.30) | TSHRNAPRTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1227721-A4 | NOVEL SUBSTITUTED SUCCINIC ACID METALLO-BETA-LACTAMASE INHIBITORS AND THEIR USE IN TREATING BACTERIAL INFECTIONS | MERCK & CO INC (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-1227722-A1 | NOVEL SUCCINIC ACID METALLO-BETA-LACTAMASE INHIBITORS AND THEIR USE IN TREATING BACTERIAL INFECTIONS | Merck & Co., Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1227721-A1 | NOVEL SUBSTITUTED SUCCINIC ACID METALLO-BETA-LACTAMASE INHIBITORS AND THEIR USE IN TREATING BACTERIAL INFECTIONS | Merck & Co., Inc. (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001030149-A1 | NOVEL SUCCINIC ACID METALLO-BETA-LACTAMASE INHIBITORS AND THEIR USE IN TREATING BACTERIAL INFECTIONS | MERCK & CO., INC. (US) | 2001-05-03 | — | — | WO | disclosed |
| WO-2001030148-A1 | NOVEL SUBSTITUTED SUCCINIC ACID METALLO-BETA-LACTAMASE INHIBITORS AND THEIR USE IN TREATING BACTERIAL INFECTIONS | MERCK & CO., INC. (US) | 2001-05-03 | — | — | WO | disclosed |