Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641592 | 0.86 | CYP1A2 (0.51) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL13157756 | 0.82 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL14297358 | 0.82 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL3815685 | 0.80 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL6024562 | 0.80 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL12301890 | 0.78 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL14500184 | 0.78 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL16418403 | 0.77 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL13655599 | 0.77 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL10192063 | 0.76 | TDP1 (0.58) | NPC1RAB9ASMN1; SMN2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | disclosed |