Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | UBE2M | P61081 | 3/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25908757 | 0.72 | CHRNA7 (0.46) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL4275205 | 0.70 | CHRNA7 (0.44) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL9533470 | 0.69 | KMT2A (0.77) | MEN1KMT2ASMN1; SMN2TP53TSHR | |
| SCHEMBL19781780 | 0.68 | MEN1 (0.53) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL16727581 | 0.68 | KMT2A (0.49) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL25908578 | 0.68 | KMT2A (0.52) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL31145098 | 0.68 | KMT2A (0.52) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL22084261 | 0.67 | MEN1 (0.56) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL28708297 | 0.67 | MEN1 (0.56) | MEN1KMT2ACHRNA7SMN1; SMN2TP53 | |
| SCHEMBL1588423 | 0.67 | KMT2A (0.69) | MEN1KMT2ASMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448554-A1 | PROPYLCARBAMATE DERIVATIVES AS INHIBITORS OF SERINE AND CYSTEINE PROTEASES | SmithKline Beecham Corporation (US) | 2004-08-25 | — | — | EP | claimed |
| WO-2003031437-A1 | PROPYLCARBAMATE DERIVATIVES AS INHIBITORS OF SERINE AND CYSTEINE PROTEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-17 | — | — | WO | claimed |
| EP-1448554-A1 | PROPYLCARBAMATE DERIVATIVES AS INHIBITORS OF SERINE AND CYSTEINE PROTEASES | SmithKline Beecham Corporation (US) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003031437-A1 | PROPYLCARBAMATE DERIVATIVES AS INHIBITORS OF SERINE AND CYSTEINE PROTEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-17 | — | — | WO | disclosed |