Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 20/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6690349 | 0.90 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6614308 | 0.80 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6616745 | 0.77 | CDK2 (0.49) | SLC6A4SLC6A3 | |
| SCHEMBL6614702 | 0.77 | SLC6A4 (0.52) | SLC6A4 | |
| SCHEMBL6651084 | 0.77 | SLC6A4 (0.43) | SLC6A4 | |
| SCHEMBL20078269 | 0.76 | GUSB (0.50) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL6614577 | 0.75 | SLC6A4 (0.51) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6618506 | 0.75 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3HTR1ADRD1 | |
| SCHEMBL4351898 | 0.70 | GUSB (0.51) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL16801518 | 0.70 | MEN1 (0.48) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373203-A1 | CYCLOPROPYLINDOLE DERIVATIVES AS SELECTIVE SEROTONIN REUPTAKE INHIBITORS | Bristol-Myers Squibb Company (US) | 2004-01-02 | — | — | EP | claimed |
| WO-2002079152-A1 | CYCLOPROPYLINDOLE DERIVATIVES AS SELECTIVE SEROTONIN REUPTAKE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2002-10-10 | — | — | WO | claimed |