Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8817791 | 0.92 | HRH4 (0.50) | HRH4HRH3CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL28217398 | 0.84 | HRH4 (0.70) | HRH4HRH3 | |
| SCHEMBL23036786 | 0.78 | HRH4 (0.43) | HRH4HRH3CRHBPCRHR2SMN1; SMN2 | |
| SCHEMBL1615966 | 0.77 | HRH4 (0.61) | HRH4HRH3 | |
| SCHEMBL5750310 | 0.77 | HRH4 (0.61) | HRH4HRH3 | |
| SCHEMBL12250775 | 0.76 | HRH4 (0.42) | HRH4 | |
| SCHEMBL28600011 | 0.76 | HRH4 (0.59) | HRH4HRH3 | |
| SCHEMBL30488040 | 0.76 | HRH4 (0.59) | HRH4HRH3 | |
| SCHEMBL24309619 | 0.76 | HRH4 (0.59) | HRH4HRH3 | |
| SCHEMBL8321238 | 0.76 | HRH4 (0.59) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377573-A2 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002048148-A2 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2002-06-20 | — | — | WO | disclosed |