Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | MAT2A | P31153 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29306052 | 0.87 | KDM4C (0.45) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL3436381 | 0.83 | KDM4E (0.49) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL30334651 | 0.83 | KDM4E (0.50) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL14405817 | 0.81 | KDM4E (0.44) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL4397813 | 0.81 | KDM4E (0.46) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL22719033 | 0.80 | HPGD (0.46) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL904681 | 0.79 | KDM4E (0.49) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL18339245 | 0.79 | KDM4E (0.45) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL22719032 | 0.78 | SMN1; SMN2 (0.47) | KDM4EMAOAMAOBKDM4CMAPT | |
| SCHEMBL22032485 | 0.77 | KDM4E (0.49) | KDM4EMAOAMAOBKDM4CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1418916-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-05-19 | — | — | EP | disclosed |
| WO-2003018022-A1 | 2-AMINO-4-HETEROARYLAMINOPYRIMIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-03-06 | — | — | WO | disclosed |