Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 12/20 | 0.48 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617870 | 0.84 | GRIA4 (0.53) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5877720 | 0.82 | GRIA4 (0.51) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6618597 | 0.81 | GRIA4 (0.48) | GRIA4GRIA2GRIA1GRIA3PKM | |
| SCHEMBL5877873 | 0.80 | GRIA4 (0.57) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5878069 | 0.79 | GRIA4 (0.56) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6615924 | 0.79 | GRIA4 (0.50) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6615524 | 0.76 | GRIA4 (0.52) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5877855 | 0.75 | GRIA4 (0.51) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6565117 | 0.75 | GRIA4 (0.77) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6616141 | 0.72 | GRIA4 (0.48) | GRIA4GRIA2GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100497-B1 | HETEROCYCLYL SULPHONAMIDE DERIVATIVES | LILLY CO ELI (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6358982-B1 | FOR THERAPY OF CENTRAL NERVOUS SYSTEM (CNS) DISORDERS | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |