⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614962 | 1.00 | — | — | |
| SCHEMBL6618396 | 0.90 | TP53 (0.56) | — | |
| SCHEMBL6618392 | 0.90 | TP53 (0.56) | — | |
| SCHEMBL6615595 | 0.89 | TP53 (0.48) | — | |
| SCHEMBL6615593 | 0.89 | TP53 (0.48) | — | |
| SCHEMBL6616845 | 0.88 | KMT2A (0.59) | — | |
| SCHEMBL6616848 | 0.88 | KMT2A (0.59) | — | |
| SCHEMBL6617006 | 0.87 | KMT2A (0.59) | — | |
| SCHEMBL6617002 | 0.87 | KMT2A (0.59) | — | |
| SCHEMBL6621012 | 0.86 | TP53 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964860-B1 | ATROPISOMERS OF 3-HETEROARYL-4(3H)-QUINAZOLINONES FOR THE TREATMENT OF NEURODEGENERATIVE AND CNS-TRAUMA RELATED CONDITIONS | PFIZER PROD INC (US) | 2004-04-21 | — | — | EP | claimed |
| US-6136812-A | Methods of administering AMPA receptor antagonists to treat dyskinesias associated with dopamine agonist therapy | PFIZER INC (US) | 2000-10-24 | — | — | US | claimed |
| CN-1248254-A | Atropisomers of 3-heteroaryl-4(3H)-quinazolinones for treatment of neurodegenerative and CNS-trauma related conditions | PFIZER PROD INC (US) | 2000-03-22 | — | — | CN | claimed |
| EP-0900568-A2 | AMPA antagonists for the treatment of dyskinesias associated with dopamine agonist therapy | Pfizer Products Inc. (US) | 1999-03-10 | — | — | EP | claimed |
| US-20200397751-A1 | Modulation of AMPA/kainate Receptors for the Treatment of Hypoglycemia | VANDERKLISH PETER (US) | 2020-12-24 | — | — | US | disclosed |
| WO-2019113110-A2 | MODULATION OF AMPA/KAINATE RECEPTORS FOR THE TREATMENT OF HYPOGLYCEMIA | VANDERKLISH PETER (US) | 2019-06-13 | — | — | WO | disclosed |
| EP-0964860-B1 | ATROPISOMERS OF 3-HETEROARYL-4(3H)-QUINAZOLINONES FOR THE TREATMENT OF NEURODEGENERATIVE AND CNS-TRAUMA RELATED CONDITIONS | PFIZER PROD INC (US) | 2004-04-21 | — | — | EP | disclosed |
| US-6380204-B1 | ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR ANTAGONIST ACTIVITY | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| US-6136812-A | Methods of administering AMPA receptor antagonists to treat dyskinesias associated with dopamine agonist therapy | PFIZER INC (US) | 2000-10-24 | — | — | US | disclosed |
| CN-1248254-A | Atropisomers of 3-heteroaryl-4(3H)-quinazolinones for treatment of neurodegenerative and CNS-trauma related conditions | PFIZER PROD INC (US) | 2000-03-22 | — | — | CN | disclosed |
| EP-0900568-A2 | AMPA antagonists for the treatment of dyskinesias associated with dopamine agonist therapy | Pfizer Products Inc. (US) | 1999-03-10 | — | — | EP | disclosed |