SCHEMBL6615741

SCHEMBL6615741

N#Cc1ccc(NC(=NN)C(F)(F)F)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.50
IDO1 P14902 1/20 0.47
HDAC1 Q13547 1/20 0.46
HDAC7 Q8WUI4 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
CA1 P00915 3/20 0.45
CA2 P00918 3/20 0.45
CA12 O43570 2/20 0.45
CA9 Q16790 2/20 0.45
ABCC9 O60706 4/20 0.44
KCNJ11 Q14654 4/20 0.44
MAPT P10636 3/20 0.42
LMNA P02545 2/20 0.42
TSHR P16473 1/20 0.42
HTT P42858 1/20 0.42
NLRP3 Q96P20 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
SAE1 Q9UBE0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6616079 0.77 GRIN2D (0.49) HDAC1HDAC7HDAC8MAPTHTT
SCHEMBL6616082 0.77 GRIN2D (0.49) HDAC1HDAC7HDAC8MAPTHTT
SCHEMBL5785443 0.74 HDAC1 (0.69) MLYCDIDO1HDAC1HDAC7HDAC8
SCHEMBL6132425 0.73 CYP1B1 (0.49) MLYCDIDO1HDAC1HDAC7HDAC8
SCHEMBL6132428 0.73 CYP1B1 (0.49) MLYCDIDO1HDAC1HDAC7HDAC8
SCHEMBL20941785 0.70 HDAC1 (0.65) MLYCDIDO1HDAC1HDAC7HDAC8
SCHEMBL20941781 0.68 MAPT (0.56) MLYCDIDO1HDAC1HDAC7HDAC8
SCHEMBL20941784 0.68 HDAC1 (0.66) MLYCDHDAC1HDAC7HDAC8HDAC6
SCHEMBL28438914 0.68 IDO1 (0.62) MLYCDIDO1HDAC1HDAC7HDAC8
SCHEMBL20941547 0.68 HDAC1 (0.61) MLYCDHDAC1HDAC7HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1442026-A1 TRIAZOLE DERIVATIVES AS CYCLOOXYGENASE (COX) INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-08-04 EP disclosed
WO-2003040110-A1 TRIAZOLE DERIVATIVES AS CYCLOOXYGENASE (COX) INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2003-05-15 WO disclosed