Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | NAMPT | P43490 | 5/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616599 | 0.95 | KMT2A (0.43) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6621197 | 0.91 | KDM5A (0.41) | KMT2AMEN1CYP2D6CYP2C9LMNA | |
| SCHEMBL6618662 | 0.90 | KMT2A (0.38) | KMT2AMEN1CYP2D6CYP2C19LMNA | |
| SCHEMBL6609241 | 0.89 | KMT2A (0.45) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6616688 | 0.89 | AAK1 (0.37) | KMT2AMEN1CYP1A2GAATSHR | |
| SCHEMBL6614370 | 0.87 | KMT2A (0.45) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6616172 | 0.87 | KMT2A (0.40) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6619183 | 0.86 | NAMPT (0.40) | KMT2AMEN1NAMPTHTT | |
| SCHEMBL6656920 | 0.86 | KMT2A (0.34) | KMT2AMEN1CYP1A2CYP3A4GAA | |
| SCHEMBL6604966 | 0.85 | KMT2A (0.42) | KMT2AMEN1CYP1A2CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |