SCHEMBL6616319

SCHEMBL6616319

O=C1C(NS(=O)(=O)c2ccc3cc(Cl)ccc3c2)CCN1c1ccc(-c2ncccc2Cl)cc1F

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6360464 1.00 F10 (0.76) F10
SCHEMBL6362733 0.90 F10 (0.80) F10
SCHEMBL6367612 0.89 F10 (0.82) F10
SCHEMBL6613850 0.86 F10 (1.00) F10
SCHEMBL6361827 0.86 F10 (1.00) F10
SCHEMBL6366482 0.86 F10 (1.00) F10
SCHEMBL6362334 0.86 F10 (1.00) F10
SCHEMBL6362233 0.85 F10 (1.00) F10
SCHEMBL6362521 0.85 F10 (0.81) F10
SCHEMBL6613008 0.85 F10 (0.81) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1456172-A1 PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS GLAXO GROUP LIMITED (GB) 2004-09-15 EP disclosed
WO-2003053925-A1 PYRROLIDINE-2-ONES AS FACTOR XA INHIBITORS GLAXO GROUP LIMITED (GB) 2003-07-03 WO disclosed