Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 3/20 | 0.49 |
| ▸ | FLT3 | P36888 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617887 | 1.00 | NPC1 (0.57) | NPC1MAPK1KDRFLT3RAB9A | |
| SCHEMBL6621230 | 0.86 | MAPK1 (0.49) | NPC1MAPK1KDRFLT3RAB9A | |
| SCHEMBL6618612 | 0.86 | MAPK1 (0.49) | NPC1MAPK1KDRFLT3RAB9A | |
| SCHEMBL6617130 | 0.83 | BCHE (0.54) | NPC1MAPK1KDRFLT3RAB9A | |
| SCHEMBL6619870 | 0.83 | BCHE (0.54) | NPC1MAPK1KDRFLT3RAB9A | |
| SCHEMBL6623309 | 0.81 | MAPK1 (0.53) | NPC1MAPK1KDRFLT3RAB9A | |
| SCHEMBL6620107 | 0.81 | MAPK1 (0.53) | NPC1MAPK1KDRFLT3RAB9A | |
| SCHEMBL6618374 | 0.81 | MAP3K11 (0.55) | NPC1MAPK1RAB9APDGFRBSMN1; SMN2 | |
| SCHEMBL6618763 | 0.81 | MAP3K11 (0.55) | NPC1MAPK1RAB9APDGFRBSMN1; SMN2 | |
| SCHEMBL8103281 | 0.80 | FGFR1 (0.45) | NPC1MAPK1KDRFLT3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |