Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.35 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15114260 | 0.77 | MEN1 (0.45) | MEN1KMT2ACYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL15114265 | 0.75 | MEN1 (0.41) | MEN1KMT2ACYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL15114269 | 0.71 | MEN1 (0.42) | MEN1KMT2ACYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL6616102 | 0.70 | MEN1 (0.45) | MEN1KMT2ACYP2C19CYP2D6ALDH1A1 | |
| SCHEMBL14198229 | 0.70 | MEN1 (0.50) | MEN1KMT2ACYP2C19ALDH1A1NPC1 | |
| SCHEMBL12890741 | 0.69 | — | — | |
| SCHEMBL3583453 | 0.66 | MEN1 (0.46) | MEN1KMT2ACYP2C19ALDH1A1NPC1 | |
| SCHEMBL1420783 | 0.64 | EPHX2 (0.46) | MEN1KMT2ACYP2C19ALDH1A1NPC1 | |
| SCHEMBL12797027 | 0.63 | NPC1 (0.53) | MEN1KMT2ACYP2C19ALDH1A1NPC1 | |
| SCHEMBL13585818 | 0.63 | NPC1 (0.53) | MEN1KMT2ACYP2C19ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490341-A1 | NOVEL ADAMANTANE DERIVATIVES | AstraZeneca AB (SE) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003080579-A1 | NOVEL ADAMANTANE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-02 | — | — | WO | disclosed |