Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.48 |
| ▸ | PDE4A | P27815 | 18/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620093 | 0.92 | PDE4A (0.38) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6621241 | 0.86 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4869227 | 0.86 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4872193 | 0.86 | PDE4B (0.52) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4869453 | 0.85 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4869968 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4873029 | 0.84 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7251478 | 0.84 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4873477 | 0.83 | MLNR (0.47) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4871545 | 0.83 | PDE4A (0.46) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086076-B1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2004-12-22 | — | — | EP | claimed |
| EP-1086076-B1 | SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE | VERTEX PHARMA (US) | 2004-12-22 | — | — | EP | disclosed |