Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617220 | 1.00 | MEN1 (0.54) | MEN1KMT2APOLB | |
| SCHEMBL6600721 | 0.83 | MEN1 (0.61) | MEN1KMT2A | |
| SCHEMBL6600719 | 0.83 | MEN1 (0.61) | MEN1KMT2A | |
| SCHEMBL6623590 | 0.81 | MEN1 (0.62) | MEN1KMT2APOLB | |
| SCHEMBL6623592 | 0.81 | MEN1 (0.62) | MEN1KMT2APOLB | |
| SCHEMBL6601524 | 0.80 | MEN1 (0.58) | MEN1KMT2A | |
| SCHEMBL6601529 | 0.80 | MEN1 (0.58) | MEN1KMT2A | |
| SCHEMBL6600612 | 0.80 | — | — | |
| SCHEMBL6600609 | 0.80 | — | — | |
| SCHEMBL6616545 | 0.77 | TP53 (0.63) | KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901487-B9 | 2,3,6 TRISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-0901487-B1 | 2,3,6 TRISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |
| EP-0901487-A1 | NOVEL 2,3 DISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043276-A1 | NOVEL 2,3 DISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER INC. (US) | 1997-11-20 | — | — | WO | disclosed |