Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.70 |
| ▸ | PREP | P48147 | 1/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605407 | 0.82 | DPP4 (1.00) | DPP4PREPDPP8DPP9DPP7 | |
| SCHEMBL5215649 | 0.82 | DPP4 (1.00) | DPP4PREPDPP8DPP9DPP7 | |
| Hydrochloric Acid SCHEMBL5218591 | 0.81 | DPP4 (0.98) | DPP4PREPDPP8DPP9DPP7 | |
| SCHEMBL14741020 | 0.73 | KDM4E (0.56) | DPP4PREPDPP8DPP9DPP7 | |
| SCHEMBL16567891 | 0.73 | KDM4E (0.56) | DPP4PREPDPP8DPP9DPP7 | |
| SCHEMBL20346556 | 0.73 | KDM4E (0.65) | DPP4CTSSCTSKKDM4ETP53 | |
| SCHEMBL9176481 | 0.72 | DPP4 (0.52) | DPP4HTR7HTR1ACTSSCTSK | |
| SCHEMBL5215339 | 0.72 | DPP4 (0.83) | DPP4PREPDPP8DPP9DPP7 | |
| Hydrochloric Acid SCHEMBL5216724 | 0.72 | DPP4 (0.82) | DPP4PREPDPP8DPP9DPP7 | |
| SCHEMBL14587275 | 0.71 | DPP4 (0.80) | DPP4PREPDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399433-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002553-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |