Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27704578 | 0.85 | NR1H2 (0.48) | NR1H2NR1H3STSGPR119KDM4E | |
| SCHEMBL27132918 | 0.81 | NR1H2 (0.47) | NR1H2NR1H3STSGPR119KDM4E | |
| SCHEMBL26984263 | 0.81 | NR1H2 (0.47) | NR1H2NR1H3STSGPR119KDM4E | |
| SCHEMBL31449997 | 0.79 | SMN1; SMN2 (0.42) | STSALDH1A1SMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL27770764 | 0.77 | SMN1; SMN2 (0.40) | STSALDH1A1SMN1; SMN2PTPN2PTPN1 | |
| SCHEMBL4976100 | 0.76 | NR1H2 (0.46) | NR1H2NR1H3GPR119RORCTSHR | |
| SCHEMBL4068506 | 0.76 | NR1H2 (0.46) | NR1H2NR1H3GPR119RORCTSHR | |
| SCHEMBL28815574 | 0.75 | NR1H2 (0.53) | NR1H2NR1H3GPR119RORCTSHR | |
| SCHEMBL18642718 | 0.75 | NR1H2 (0.53) | NR1H2NR1H3GPR119RORCTSHR | |
| SCHEMBL16004573 | 0.75 | NR1H2 (0.53) | NR1H2NR1H3GPR119RORCTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395574-A1 | 4-(PHENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | AstraZeneca AB (SE) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094810-A1 | 4-(PHENYL-PIPERIDIN-4-YLIDENE-METHYL)-BENZAMIDE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF PAIN, ANXIETY OR GASTROINTESTINAL DISORDERS | ASTRAZENECA AB (SE) | 2002-11-28 | — | — | WO | disclosed |