Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.52 |
| ▸ | MARK3 | P27448 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 4/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620015 | 0.94 | LCK (0.51) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6619365 | 0.89 | LCK (0.63) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6621515 | 0.88 | FGFR4 (0.52) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6619325 | 0.88 | EGFR (0.48) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6621317 | 0.88 | EGFR (0.50) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6619180 | 0.87 | FGFR4 (0.54) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6622549 | 0.86 | LCK (0.69) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6621208 | 0.86 | EGFR (0.49) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6619250 | 0.86 | EGFR (0.49) | LCKMAPK14SIK2EGFRFGFR4 | |
| SCHEMBL6619123 | 0.85 | LCK (0.51) | LCKMAPK14SIK2EGFRFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123295-B1 | BICYCLIC NITROGEN HETEROCYCLES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| EP-1123295-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| US-6150373-A | AMINO-SUBSTITUTED DIHYDROPYRIMIDO(4,5-D)PYRIMIDINONE DERIVATIVES; INHIBITORS OF THE T-CELL TYROSINE KINASE P56LCK; IMMUNOSUPPRESSANTS; ANTIINFLAMMATORY/-CARCINOGENIC AGENTS; BRONCHOPULMONARY, DERMATOLOGICAL AND CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-2000024744-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | disclosed |