Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618137 | 1.00 | CDC7 (0.50) | CDC7MAPK1TGFBR1TGFBR2NOS1 | |
| SCHEMBL8112788 | 1.00 | CDC7 (0.50) | CDC7MAPK1TGFBR1TGFBR2NOS1 | |
| SCHEMBL6616714 | 0.86 | MAPK1 (0.44) | CDC7MAPK1TGFBR1TGFBR2NOS1 | |
| SCHEMBL6617657 | 0.86 | MAPK1 (0.44) | CDC7MAPK1TGFBR1TGFBR2NOS1 | |
| SCHEMBL6616738 | 0.85 | SMN1; SMN2 (0.58) | CDC7MAPK1DYRK1AKDRROCK2 | |
| SCHEMBL8111020 | 0.84 | CDC7 (0.47) | CDC7MAPK1TGFBR1IDO1NPC1 | |
| SCHEMBL6617130 | 0.84 | BCHE (0.54) | MAPK1TGFBR1IDO1KDRROCK2 | |
| SCHEMBL6617279 | 0.84 | BCHE (0.54) | CDC7MAPK1DYRK1AIDO1KDR | |
| SCHEMBL6616183 | 0.84 | EGFR (0.47) | MAPK1NOS1DYRK1AIDO1KDR | |
| SCHEMBL6617105 | 0.84 | EGFR (0.47) | MAPK1NOS1DYRK1AIDO1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |