Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 8/20 | 0.46 |
| ▸ | BMX | P51813 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622724 | 0.86 | TNK2 (0.43) | FGFR4BMXEGFRCSF1RFGFR1 | |
| SCHEMBL6070019 | 0.85 | FGFR4 (0.40) | FGFR4BMXFGFR1TNK2MAP4K2 | |
| SCHEMBL6623008 | 0.85 | FGFR4 (0.43) | FGFR4EGFRCSF1RALDH1A1 | |
| SCHEMBL30837054 | 0.82 | FGFR4 (0.51) | FGFR4EGFRFGFR1TNK2MAP4K2 | |
| SCHEMBL6620595 | 0.82 | FGFR4 (0.51) | FGFR4EGFRFGFR1TNK2MAP4K2 | |
| SCHEMBL15413275 | 0.81 | FGFR4 (0.68) | FGFR4BMXFGFR1FGFR2FGFR3 | |
| SCHEMBL15434046 | 0.80 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL29546170 | 0.80 | FGFR4 (0.60) | FGFR4FGFR1FGFR2FGFR3KDR | |
| SCHEMBL6618886 | 0.79 | FGFR4 (0.72) | FGFR4BMXEGFRCSF1RFGFR1 | |
| SCHEMBL6625602 | 0.79 | FGFR4 (0.40) | FGFR4BMXEGFRCSF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123295-B1 | BICYCLIC NITROGEN HETEROCYCLES | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| EP-1123295-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| US-6150373-A | AMINO-SUBSTITUTED DIHYDROPYRIMIDO(4,5-D)PYRIMIDINONE DERIVATIVES; INHIBITORS OF THE T-CELL TYROSINE KINASE P56LCK; IMMUNOSUPPRESSANTS; ANTIINFLAMMATORY/-CARCINOGENIC AGENTS; BRONCHOPULMONARY, DERMATOLOGICAL AND CARDIOVASCULAR DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-2000024744-A1 | BICYCLIC NITROGEN HETEROCYCLES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-05-04 | — | — | WO | disclosed |