Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619064 | 0.92 | EGFR (0.45) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6617924 | 0.92 | EGFR (0.46) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6616828 | 0.91 | EGFR (0.46) | EGFRERBB2KCNH2SRCKDR | |
| SCHEMBL6613963 | 0.90 | EGFR (0.47) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6617308 | 0.90 | SLC6A2 (0.45) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6620697 | 0.89 | SLC6A2 (0.42) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6616348 | 0.88 | EGFR (0.49) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6621804 | 0.88 | ERBB2 (0.41) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6618997 | 0.87 | EGFR (0.49) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 | |
| SCHEMBL6656941 | 0.84 | EGFR (0.50) | EGFRSLC6A2SLC6A4SLC6A3ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1444210-A1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | claimed |
| WO-2003040108-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | claimed |
| EP-1444210-A1 | QUNAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | AstraZeneca AB (SE) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003040108-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ASTRAZENECA AB (SE) | 2003-05-15 | — | — | WO | disclosed |