Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19991262 | 0.86 | HTT (0.67) | HTTTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL12581339 | 0.85 | TDP1 (0.49) | HTTALDH1A1RAB9ANPC1HSP90AA1 | |
| SCHEMBL6621432 | 0.80 | HTT (0.67) | HTTTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL4573001 | 0.80 | HTT (0.67) | HTTTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL8653789 | 0.79 | PRSS1 (0.52) | HTTTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL5726306 | 0.79 | HTT (0.52) | HTTTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL12680354 | 0.78 | CYP4A11 (0.55) | ALDH1A1MAPTALOX12HPGDCYP2C9 | |
| SCHEMBL15864554 | 0.77 | HTT (0.58) | HTTTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL26227594 | 0.77 | HTT (0.71) | HTTTSHRALDH1A1RAB9ANPC1 | |
| SCHEMBL11974036 | 0.77 | HTT (0.71) | HTTTSHRALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487827-A1 | ANTI-INFLAMMATORY MORPHOLIN-ACETAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082862-A1 | ANTI-INFLAMMATORY MORPHOLIN-ACETAMIDE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-10-09 | — | — | WO | disclosed |